Franco

The mitochondrion is a double membrane structured organelle involved in a variety of regulatory functions such as calcium signaling, production of adenosine triphosphate, apoptosis, reactive oxygen species generation, cell growth, and cell cycling. Impaired mitochondrial function is evident in various neurological disorders stemming from both…[Read more]

NGS revealed TP53 as the most frequently mutated gene. The rate of HER2 positive cases and MSI-H cases were 9.5% (4/42) and 12.2% (5/41), respectively. Among these 42 cases, there was no molecular and clinicopathological differences according to the presence of tumor cells with clear cytoplasm. Enteroblastic marker-positive CRC could be grouped…[Read more]

Introduction Focal therapy (FT) for localized prostate cancer (PCa) is a promising treatment strategy. Although, according to guidelines, it should be regarded as an experimental option, its introduction into clinical practice has occurred at an accelerated speed. It is, thus, crucial for Urologists to understand FT limitations and potential…[Read more]

But, these theories lead to a “hit and miss” scenario because, they do explain certain features (increase/decrease in axon diameter) but miss to explain, correlation between the strength of stimuli and spike rate of AP. Bio-physical models of nerve membrane are thus important for enhancing our understanding regarding the governing dynamics of…[Read more]

Objectives To investigate the full publication proportion (FPP) of abstracts presented at the 2010 and 2011 EAO Congresses, analyse the discrepancies between abstracts and their full publications, and explore potential predictors of FPP and discrepancies. Methods Abstracts presented at the 2010 and 2011 EAO Congresses were retrieved. Associated…[Read more]

In addition, ciRS-7 up-regulation was closely associated with tumor diameter (P = 0.050), clinical stage (P = 0.009), and distant metastasis (P = 0.007). ciRS-7 knockdown in 786O and 769P cells markedly inhibited their proliferative and invasive abilities. In addition, ciRS-7 inhibition reduced phosphorylated epidermal growth factor receptor…[Read more]