Wichmann

There is a paucity of empirical studies exploring wishes to die (WTD) in older adults without a life-threatening disease or psychiatric disorder, especially on how these WTD evolve over time.

This study aims to deepen our understanding of living with a WTD by elucidating multifaceted trajectories of death wishes in older adults without a…[Read more]

The causes for disparities in implementation of precision medicine are complex, due in part to differences in clinical care and a lack of engagement and recruitment of under-represented populations in studies. New tools and large genetic cohorts can change these circumstances and build access to personalized medicine for disadvantaged…[Read more]

Environmental problems caused by mines have been increasing. As one of the most serious types of mining damage caused to the eco-environment, open pits have been the focus of monitoring and management. Previous studies have obtained effective results when evaluating the ecological quality of a mining area by using the remote sensing ecological…[Read more]

0%; work impairment, 37.1% vs. 23.3%; overall activity impairment, 39.8% vs. 25.3%; all p  less then  0.05). CONCLUSION HRQoL and work productivity were significantly impacted in TIRs versus TRs in this real-world analysis of patients with migraine acutely treated with triptans, highlighting the need for more effective treatments for patients wit…[Read more]

Recent advances in data analytics and computer-aided diagnostics stimulate the vision of patient-centric precision healthcare, where treatment plans are customized based on the health records and needs of every patient. In physical rehabilitation, the progress in machine learning and the advent of affordable and reliable motion capture sensors…[Read more]

BACKGROUND & AIMS Quantification of eosinophilic esophagitis (EoE) symptoms is crucial for assessing treatment outcomes. We aimed to explore the effect of budesonide oral suspension (BOS) on dysphagia and pain with swallowing. METHODS We performed a secondary analysis of data from a phase 2 multicenter, double-blind, trial (conducted from July…[Read more]

The interaction between nocodazole (Nz) and human serum albumin (HSA) under controlled physiological condition (pH 7.4) is examined using absorption, emission, fluorescence lifetime (FLT) and circular dichroism (CD) spectroscopic techniques. The binding constant (order of 105 M-1) from UV-vis and fluorescence spectroscopy reveals a strong…[Read more]

A total of 29.3% of patients were discharged. These findings suggest that the increasing use of remote follow-up in carefully selected subgroups can facilitate efficient and acceptable healthcare delivery. Although ‘in-person’ clinical appointments will continue to be regarded as the default safe and gold standard management modality, OMFS…[Read more]

Mast cells are rare tissue-resident cells of importance to human allergies. To understand the structural basis of principle mast cell functions, we analyzed the proteome of primary human and mouse mast cells by quantitative mass spectrometry. We identified a mast-cell-specific proteome signature, indicative of a unique lineage, only distantly…[Read more]

Zinc (Zn) is one of the most important trace elements in the body and is required for insulin secretion and release. Zn is also required for the growth and development of the reproductive system. Alteration in the Zn levels can cause moderate to severe damage to various organs, including the reproductive system. Most of type 2 diabetic patients…[Read more]

039) were significantly higher in HP than in CAD. No significant difference appeared in Sfv (CAD -0.27 ± 0.07 N.kg-1.m.s-1 vs. HS -0.28 ± 0.07 N.kg-1.m.s-1, p = 0.541). Conclusion The lower maximal power in CAD patients was related to both a lower V 0 and F 0. Physical inactivity, sedentary time and high cardiovascular disease (CVD) risk may e…[Read more]