Mathiesen

In recent years, 5-pyrazolyl-ureas have mostly been known for their attractive poly-pharmacological outline and, in particular, ethyl 1-(2-hydroxypentyl)-5-(3-(3-(trifluoromethyl) phenyl) ureido)-1H-pyrazole-4-carboxylate (named GeGe-3) has emerged as a capable anti-angiogenic compound. This paper examines its interactome by functional proteomics…[Read more]

A new technique, to the best of our knowledge, for improving the axial resolution and imaging contrast of a reflection mode confocal microscope is proposed. A 50 µm silica microsphere is added in front of the objective lens to enhance both the focusing of illumination and the collection of reflected and scattered light from sample surfaces in…[Read more]

nitive performance and had 56% higher odds of caregiver distress (OR = 1.56; 95% CI 1.43 to 1.71).

In our cohort of non-cancer patients dying in the community, pain, shortness of breath, impaired cognitive function and caregiver distress are important symptoms to manage near the end of life even in non-institutional settings.

In our…[Read more]

Seminolipid (also known as sulfogalactosylglycerolipid-SGG), present selectively in male germ cells, plays important roles in spermatogenesis and sperm-egg interaction. selleck inhibitor The proper degradation of SGG in apoptotic germ cells is also as important. Sertoli cells first phagocytose apoptotic germ cells, then Sertoli lysosomal…[Read more]