Meredith

Microglial activation is believed to play a role in many psychiatric and neurodegenerative diseases. Based largely on evidence from other cell types, it is widely thought that MAP kinase (ERK, JNK and p38) signalling pathways contribute strongly to microglial activation following immune stimuli acting on toll-like receptor (TLR) 3 or TLR4. We…[Read more]

8% (p<0.001) in workshop 1, 26.8% (p<0.001) in workshop 2, 24.9% (p<0.001) in workshop 3, and 18.6% (p<0.001) in workshop 4, with an overall mean of 22.4% (p<0.001) knowledge gained for all four workshops. Nurses reported an increase in skill, comfort, and preparedness at 18months for workshop 1, 2, and 3 and in skill and comfort at 12months for…[Read more]

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS), characterized by demyelination, gliosis, and neurodegeneration. While the currently available disease-modifying therapies effectively suppress the immune attack on the CNS, there are no therapies to date that directly mitigate neurodegeneration.…[Read more]

Specifically, we generated surface electric field magnitude plots for the brain and for structures considered most relevant to GVS mechanism of action- the semi-circular canals (SCC) and the otolith.Findings show that the Bilateral-Bipolar configuration results in the most spatially restricted flow while the Unilateral-Monopolar configuration…[Read more]

CONCLUSIONS IDD were present in the last common ancestor of Streptophyta. On land, IDD duplicated extensively originating ten lineages. Later, IDD were recruited by angiosperms where they diversified greatly in number; C-terminal and expression patterns accompanying important aspects of plant body evolution.This study provides a solid framework of…[Read more]