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Anisotropy in the localization of the percolation threshold was also observed in finite-sized packings, but it disappeared in the limit of infinitely large systems.By employing the exact enumeration technique, we study consequences of different apex angles of a wedge-shaped channel on the mean first passage time and free-energy profile of a linear polymer chain translocating from the cis- to the trans-side through an interacting pore. We investigate effects of asymmetry arising in the free-energy profile due to the change in apex angles and its dependence on the first passage time. We report the combined effect of entropy (arising due to apex angles) and pore interaction on the nonmonotonic behavior of the translocation time. The effect of different solvent quality across the channel has also been explored. We show that the increase in monomer-monomer interaction leads to the formation of globules near the pore, which drives the process faster.Living cells sense their environment through the binding of extracellular molecular ligands to cell surface receptors. Puzzlingly, vast numbers of signaling pathways exhibit a high degree of cross talk between different signals whereby different ligands act through the same receptor or shared components downstream. It remains unclear how a cell can accurately process information from the environment in such cross-wired pathways. We show that a feature which commonly accompanies cross talk-signaling pleiotropy (the ability of a receptor to produce multiple outputs)-offers a solution to the cross-talk problem. In a minimal model we show that a single pleiotropic receptor can simultaneously identify and accurately sense the concentrations of arbitrary unknown ligands present individually or in a mixture. We calculate the fundamental limits of the signaling specificity and accuracy of such signaling schemes. The model serves as an elementary “building block” toward understanding more complex cross-wired receptor-ligand signaling networks.Considering an entropy-based division of energy transferred into heat and work, we develop an alternative theoretical framework for the thermodynamic analysis of two-level systems. When comparing these results with those obtained using the standard definitions of these quantities, we observe the appearance of a different term of work, which represents the energy cost of rotating the Bloch vector in the presence of the external field that defines the local Hamiltonian. Additionally, we obtain explicit expressions for the temperature, the heat capacity, and the internal entropy production of the system in both paradigms. In order to illustrate our findings we study, from both perspectives, matter-radiation interaction processes for two different systems.Accurate phase diagrams of multicomponent plasmas are required for the modeling of dense stellar plasmas, such as those found in the cores of white dwarf stars and the crusts of neutron stars. Those phase diagrams have been computed using a variety of standard techniques, which suffer from physical and computational limitations. Here we present an efficient and accurate method that overcomes the drawbacks of previously used approaches. In particular, finite-size effects are avoided as each phase is calculated separately; the plasma electrons and volume changes are explicitly taken into account; and arbitrary analytic fits to simulation data as well as particle insertions are avoided. Furthermore, no simulations at “uninteresting” state conditions, i.e., away from the phase coexistence curves, are required, which improves the efficiency of the technique. The method consists of an adaptation of the so-called Gibbs-Duhem integration approach to electron-ion plasmas, where the coexistence curve is determined by direct numerical integration of its underlying Clapeyron equation. SBC-115076 order The thermodynamics properties of the coexisting phases are evaluated separately using Monte Carlo simulations in the isobaric semigrand canonical ensemble (NPTΔμ). We describe this Monte Carlo-based Clapeyron integration method, including its basic physical and numerical principles, our extension to electron-ion plasmas, and our numerical implementation. We illustrate its applicability and benefits with the calculation of the melting curve of dense carbon-oxygen plasmas under conditions relevant for the cores of white dwarf stars and provide analytic fits to implement this new melting curve in white dwarf models. While this work focuses on the liquid-solid phase boundary of dense two-component plasmas, a wider range of physical systems and phase boundaries are within the scope of the Clapeyron integration method, which had until now only been applied to simple model systems of neutral particles.To what spatial extent does a single lipid affect the mechanical properties of the membrane that surrounds it? The lipid composition of a membrane determines its mechanical properties. The shapes available to the membrane depend on its compositional material properties, and therefore, the lipid environment. Because each individual lipid species’ chemistry is different, it is important to know its range of influence on membrane mechanical properties. This is defined herein as the lipid’s mechanical extent. Here, a lipid’s mechanical extent is determined by quantifying lipid redistribution and the average curvature that lipid species experience on fluctuating membrane surfaces. A surprising finding is that, unlike unsaturated lipids, saturated lipids have a complicated, nonlocal effect on the surrounding surface, with the interaction strength maximal at a finite length-scale. The methodology provides the means to substantially enrich curvature-energy models of membrane structures, quantifying what was previously only conjecture.We present perturbation theory based on the inverse scattering transform method for solitons described by an equation with the inverse linear dispersion law ω∼1/k, where ω is the frequency and k is the wave number, and cubic nonlinearity. This equation, first suggested by Davydova and Lashkin for describing dynamics of nonlinear short-wavelength ion-cyclotron waves in plasmas and later known as the Fokas-Lenells equation, arises from the first negative flow of the Kaup-Newell hierarchy. Local and nonlocal integrals of motion, in particular the energy and momentum of nonlinear ion-cyclotron waves, are explicitly expressed in terms of the discrete (solitonic) and continuous (radiative) scattering data. Evolution equations for the scattering data in the presence of a perturbation are presented. Spectral distributions in the wave number domain of the energy emitted by the soliton in the presence of a perturbation are calculated analytically for two cases (i) linear damping that corresponds to Landau damping of plasma waves, and (ii) multiplicative noise which corresponds to thermodynamic fluctuations of the external magnetic field (thermal noise) and/or the presence of a weak plasma turbulence.