Beier

Responsiveness data were only available for the Gross Motor Function Measure-Challenge battery. The decision tree was developed with five levels clinical feasibility, relevance, tool design, clinical utility, and psychometric properties. INTERPRETATION High-level motor skills assessment tools have strong psychometric evidence for ambulant,…[Read more]

002). Median pre- and post-treatment CA-125 levels for LGSC patients were 295.5U/mL and 144U/mL (52% decrease) (p<0.001). The median pre- and post-treatment CA-125 levels for HGSC patients were 767.5 and 35.6 (96% decrease) (p<0.001). For LGSC patients, 4/36 (11%) had partial response (PR), 30/36 (83%) had stable disease (SD), and 2/36 (6%) had…[Read more]

The assay for transposase-accessible chromatin followed by sequencing (ATAC-seq) is an inexpensive protocol for measuring open chromatin regions. ATAC-seq is also relatively simple and requires fewer cells than many other high-throughput sequencing protocols. Therefore, it is tractable in numerous settings where other high throughput assays are…[Read more]

inib therapy, the median PFS was 7.9 months (95%CI 4.1-11.7 months). Among the 15 patients with brain metastasis, the median PFS was 6.0 months (95%CI 2.2-9.8 months). The main toxicities related to pyrotinib were diarrhea in 57 (79.2%) cases, and 48 (66.7%) cases with grade 1-2 as well as 9 (12.5%) cases with grade 3. CONCLUSION Pyrotinib based…[Read more]

The BPS intervention was associated with decreases in both the CAR and cortisol responses to acute stress. Compared to controls, BPS participants showed decreased worrying and increased positive affect post-intervention; however, they did not show the expected greater increase in optimism. Within-person decreases in worrying were associated with…[Read more]

The diameter of a micro-tube is very small and its wall thickness is very thin. Thus, when applying double-layer gas-assisted extrusion technology to process a micro-tube, it is necessary to find the suitable inlet gas pressure and a method for forming a stable double gas layer. In this study, a double-layer gas-assisted extrusion experiment is…[Read more]

We studied the effect of an amyloidogenic intrinsically disordered protein, α-synuclein, which is associated with Parkinson’s disease (PD), on the conformational dynamics of a DNA hairpin (DNA-HP) employing the single-molecule Förster resonance energy transfer method. The open-to-closed conforma-tional equilibrium of the DNA-HP is drastically a…[Read more]

69% vs 0.87%, respectively). Compared with patients with SVR, patients without SVR had a significantly higher risk of gastric cancer (0.10% vs 0.03% per person-year, P = 0.004) and non-Hodgkin lymphoma (NHL) (0.08% vs 0.03% per person-year, respectively, P = 0.03). When considering death as a competing risk, non-SVR was independently associated…[Read more]