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g., from water scarcity to low water scarcity). Approximately three quarters of people in China are affected by water transfer. More than a half of the national population (705 million) benefit from alleviated water scarcity, leading to the inequality coefficient reduced from 0.64 under natural water availability condition to 0.59 considering water transfer in 2016. However, 357 million people in water transfer source basins are subject to increased water scarcity, in which ~21% are from water stressed sub-basins. This study reveals for the first time water transfer induced water scarcity and inequality change across sub-basins in China, and highlights the challenges to secure water supply across basins.

Parkinson’s disease (PD) can present with neuropsychiatric symptoms (here, anxiety, depression, and apathy) at any stage of the disease. We investigated the neural correlates of subclinical neuropsychiatric symptoms in relation to motor and cognitive symptoms in a high-functioning PD cohort.

Brain morphometry of the cognitively intact, early-stage (Hoehn & Yahr 2) PD group (n=48) was compared to matched controls (n=37). Whole-brain, pairwise, resting-state functional connectivity measures were correlated with neuropsychiatric symptom, motor exam, and global cognitive scores of the PD group.

Factor analysis of highly collinear anxiety, depression, and apathy scores revealed a single principal component (i.e., composite neuropsychiatric symptom score) explaining 71.6% of variance. There was no collinearity between the neuropsychiatric, motor, and cognitive scores. Compared to controls, PD group showed only subcortical changes including amygdala and nucleus accumbens atrophy, and greater pallidal volumeuropsychiatric phenotyping is important and may facilitate early interventions to “reorganize” these circuits and delay/prevent clinical symptom onset.

We report the findings from the Spanish Society of Neurology’s NeuroCOVID-19 Registry.

We performed a multicentre study of patients with neurological manifestations of COVID-19. Participating physicians reported demographic, clinical, and paraclinical data and judged the involvement of COVID-19 in causing neurological symptoms.

A total of 233 cases were submitted, including 74 different combinations of manifestations. The most frequently reported were stroke (27%), neuromuscular symptoms (23.6%), altered mental status (23.6%), anosmia (17.6%), headache (12.9%), and seizures (11.6%). The mean age of patients was 61.1years, with 42.1% being women; a higher proportion of women was recorded among patients with altered mental status, anosmia, and headache. The onset of symptoms differed within categories. Onset of anosmia occurred a mean (standard deviation) of 2.9 (2.5) days after the first general symptom, whereas neuromuscular symptoms appeared after 13.9 (10.1) days. Neurological symptoms were persistental diagnoses. COVID-19 may cause persistent and disabling neurological symptoms.Immunolabeling is a technique, which has recently been introduced to enhance the quality of developed fingermarks and subsequently strengthen the evidential value. The effect of this method on subsequent DNA analysis, however, has not been explored yet. Therefore, the current pilot study aimed to determine whether STR profiling is possible after immunolabeling. Since immunolabeling involves washing steps which could reduce DNA quantities, the use of different fixatives including methanol, formaldehyde and universal molecular fixative (UMFIX) were investigated. STR profiles from the (immunolabeled) fingermarks were generated after four days and four weeks by a direct PCR method to enable comparison of relatively fresh and old fingermarks. The fingermarks were deposited on diverse forensically relevant substrates, including glass, metal and tile. STR profiles could be recovered for all tested fixatives with no significant difference in performance. However, the mean number of detected alleles was the highest when methanol was used for fixation. Furthermore, immunolabeling on aged fingermarks (4 weeks) was also possible, but the number of detected alleles showed a non-significant decrease. DNA could be recovered from deposits on all substrates, of which glass showed the highest mean number of detected alleles followed by metal and tile.In human-machine interfaces, decoder calibration is critical to enable an effective and seamless interaction with the machine. However, recalibration is often necessary as the decoder off-line predictive power does not generally imply ease-of-use, due to closed loop dynamics and user adaptation that cannot be accounted for during the calibration procedure. Here, we propose an adaptive interface that makes use of a non-linear autoencoder trained iteratively to perform online manifold identification and tracking, with the dual goal of reducing the need for interface recalibration and enhancing human-machine joint performance. Importantly, the proposed approach avoids interrupting the operation of the device and it neither relies on information about the state of the task, nor on the existence of a stable neural or movement manifold, allowing it to be applied in the earliest stages of interface operation, when the formation of new neural strategies is still on-going. In order to more directly test the performance of our algorithm, we defined the autoencoder latent space as the control space of a body-machine interface. After an initial offline parameter tuning, we evaluated the performance of the adaptive interface versus that of a static decoder in approximating the evolving low-dimensional manifold of users simultaneously learning to perform reaching movements within the latent space. Roscovitine Results show that the adaptive approach increased the representational efficiency of the interface decoder. Concurrently, it significantly improved users’ task-related performance, indicating that the development of a more accurate internal model is encouraged by the online co-adaptation process.

Alpha-1 antitrypsin deficiency (AATD) is a risk factor for liver disease. PASD-positive inclusions have been found unexpectedly in approximately 10% of liver explants in patients with no previous diagnosis of AATD, particularly, in patients with non-alcoholic steatohepatitis (NASH), supporting a synergistic mechanism of liver injury between AATD and environmental factors. We aimed to determine the clinical characteristics of mestizo patients in which AATD was diagnosed before or after liver transplantation.

Liver explants of patients with cryptogenic, alcoholic, and NAFLD/NASH cirrhosis undergoing orthotopic liver transplantation (OLT) were included. Liver histopathology was assessed by two expert pathologists. Hematoxylin and eosin staining, PASD staining, and confirmatory AAT immunohistochemistry were performed. In explants with positive histopathology, genotyping for SERPINA1 was performed.

A total of 180 liver transplants were performed during the study period. Of these, 44 patients with cryptogenic cirrhosis, NASH, and alcoholic cirrhosis were included.