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(51% vs. 39%), but there were fewer nursing device adjustments (2.9 vs. 6.2 mean adjustments intrapartum, p less then 0.01). There were no differences in physician device satisfaction scores between groups, but fetal electrocardiography generated higher patient satisfaction scores. CONCLUSION Fetal electrocardiography performed similarly to standard external monitoring when considering percentage of interpretable tracing generated in labor. Furthermore, patients reported overall greater satisfaction with fetal electrocardiography in labor. Fetal electrocardiography may be particularly useful in patients with body mass index ≥30. PURPOSE To evaluate the association between baseline psychosocial milieu and subsequent glaucoma medication adherence among participants in the Support, Educate, Empower (SEE) personalized glaucoma coaching program pilot study. DESIGN Prospective cohort study. PARTICIPANTS University of Michigan glaucoma patients ≥ age 40, taking ≥ 1 glaucoma medication, who self-reported poor adherence. METHODS Participants completed a baseline survey that assessed 1) Demographics; 2) Social network; 3) Perceived Stress; 4) Consideration of future consequences; 5) Glaucoma-related distress and 6) Social support. Medication adherence was then monitored electronically (AdhereTech, New York, NY) for 3 months and the percentage of prescribed doses taken was calculated. The relationship between baseline factors and medication adherence was assessed using univariate and multivariate analysis. MAIN OUTCOME MEASURES Median percent adherence over three months. RESULTS Of the 95 study participants, 63% had graduated from college, 55% were white, 35% were African-American, and 97% had insurance. Median adherence over three months was 74% + 21% (+ standard deviation, SD). Higher income and more education were significantly associated with better adherence (p less then 0.0001, p = 0.03). Glaucoma related distress (mean score 5.6, SD = 3.0) was inversely associated with medication adherence on univariate (p less then 0.0001) and multivariate analysis (p=0.0002). Selleck SPOP-i-6lc Every one-point increase in glaucoma related distress score predicted a 2.4 percentage-point decrease in medication adherence. CONCLUSIONS Lower income, lower educational attainment and a higher level of glaucoma-related distress all predicted lower adherence to glaucoma medications. Additional glaucoma self-management support resources should be directed towards patients with such risk factors for poor adherence. PURPOSE To investigate whether visual function can be graded in detail using pattern electroretinogram (PERG) in preperimetric to perimetric glaucoma DESIGN Cross-sectional observational study METHODS Twenty-six normal subjects, 113 preperimetric glaucoma patients (which included glaucoma suspect patients), and 52 early perimetric glaucoma patients with a mean deviation (MD) > -10dB were included. Structural and functional measurements were performed using spectral-domain optical coherence tomography and a commercial ERG stimulator, respectively. RESULTS The average retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIPL) thickness were thinnest in perimetric group followed by the preperimetric group and the control group (P less then 0.001). PERG N95 amplitude was the largest in the control group followed by the preperimetric group, and the perimetric group (P less then 0.001). Among the preperimetric glaucoma patients, the presence of the RNFL defect was associated with lower PERG N95 amplitude (P=0.013). The N95 amplitude showed a significant relationship with average RNFL thickness (r=0.336, P less then 0.001) and GCIPL thickness (r=0.376, P less then 0.001). In the preperimetric group with the RNFL defect, the N95 amplitude showed larger areas under the receiver operating characteristics curve (0.779) than the MD (0.533, P=0.005). CONCLUSIONS PERG N95 amplitudes decreased from the control to preperimetric glaucoma and were reduced more in perimetric glaucoma. The functional assessment for detecting early glaucomatous damage could be complemented by PERG N95 amplitude. Usefulness of PERG parameters except N95 amplitude seemed to be limited in a clinical setting because of relatively low diagnostic performance in preperimetric glaucoma. PURPOSE To evaluate the safety and efficacy of 0.18 mg fluocinolone acetonide intravitreal (FAi) insert in chronic non-infectious uveitis affecting the posterior segment of the eye. DESIGN Prospective, multicenter, randomized, doubled-masked, sham-controlled, 3-year, phase 3 clinical trial. METHODS Eligible patients were randomized in a 21 ratio to receive either FAi (0.18 mg) insert (N=87) or sham injection (N=42). Primary efficacy endpoint was the recurrence of uveitis within 6 months. Secondary endpoints were recurrence within 12 months, resolution of macular edema, change in best corrected visual acuity, intraocular pressure (IOP) and adverse events. RESULTS Uveitis recurrence rates were significantly lower in FAi group compared to sham at 6 (18.4 vs 78.6%; p less then 0.001) and 12 months (27.6 vs 85.7%; p less then 0.001). Through 12 months, fewer FAi subjects required adjunctive anti-inflammatory treatment; more FAi subjects had resolution of macular edema (71% vs 48%); and fewer had loss of ≥15 letters (14% vs 31%). An IOP rise of ≥12 mmHg was observed in 18.4% of FAi eyes and 9.5% of sham eyes; however, IOP-lowering medication was used in similar proportions of eyes in both groups (26% each). FAi was associated with higher rates of cataract. CONCLUSION FAi demonstrated significant benefit in extending anti-inflammatory effect and reducing the likelihood of uveitis flares through 12 months. A higher proportion of FAi eyes had elevated IOP, but IOP-lowering medication and surgeries were used in similar proportions in both groups. Additional data from this three-year study will provide further insight into the safety, efficacy, and duration of effect of this treatment. PURPOSE To test the hypothesis that the correlation between office-hour intraocular pressure (IOP) and peak nocturnal IOP is weakened after using a prostaglandin analog. DESIGN Before-and-after study. METHODS 24-hour IOP data obtained in a sleep laboratory of 51 patients (22 open angle glaucoma and 29 ocular hypertension) were reviewed. Patients had no IOP-lowering medication upon study entry and then were treated with prostaglandin monotherapy for 4 weeks. Measurements of IOP were taken every 2 hours in the sitting and supine positions during the diurnal/wake period (730 AM to 930 PM) and in the supine position during the nocturnal/sleep period (1130 PM to 530 AM). Individual and average IOP readings during office hours (930 AM to 330 PM) and peak IOP during the nocturnal/sleep hours were analyzed using Pearson’s correlation coefficient and linear regression. RESULTS There were statistically significant correlations for all the paired variables for the analyses. Average office-hour IOP had a higher correlation with peak nocturnal IOP than individual office-hour IOP.