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Accordingly, we posit that the proposed higher order robust principal component analysis based approach filters out the background phase-amplitude coupling activity and predominantly captures the event-related phase-amplitude coupling dynamics to provide insight into the spatially distributed brain networks across different frequency bands.It is…[Read more]

Methamphetamine (METH), a powerful psychoactive drug, causes damage to the nervous system and leads to degenerative changes similar to Alzheimer’s disease (AD), however, the molecular mechanism between the toxicity of METH and AD-related symptoms remains poorly understood. In this study, we investigated the effect of METH exposure on the…[Read more]

Precise gene editing techniques are paramount to gain deeper insights into the biological processes such as host-parasite interactions, drug resistance mechanisms, and gene-function relationships. Discovery of CRISPR-Cas9 system has spearheaded mechanistic understanding of protozoan parasite biology as evident from the number of reports in the…[Read more]

Poly (ADP-ribose) polymerase-1 (PARP-1) is a critical enzyme in the DNA repair process and the target of several FDA-approved inhibitors. Several of these inhibitors have been radiolabeled for non-invasive imaging of PARP-1 expression or targeted radiotherapy of PARP-1 expressing tumors. In particular, derivatives of olaparib and rucaparib, which…[Read more]

The clinical course is more favorable compared to cirrhosis patients, especially in the absence of clinical PH or liver dysfunction. There are no universally accepted guidelines in regard to diagnosis and treatment of INCPH/PSVD. Hence, this review emphasizes the need to raise awareness of this entity by highlighting its complex pathophysiology…[Read more]

For this reason, this review provides an overview of organosilicon polymers that have been reported over the past two decades.Three isomers of (trifluoromethoxy)phenylboronic acids were studied in the context of their physicochemical, structural, antimicrobial and spectroscopic properties. They were characterized by 1H, 13C, 11B and 19F NMR…[Read more]

The coronavirus disease 2019 pandemic has brought about many changes and catapulted telehealth into the mainstream of health care delivery. selleck chemicals llc Audio and video conference health care visits have become commonplace and have impacted geographic barriers and access to care issues with the potential for care coordination in our…[Read more]