Blackwell

Age is the dominant risk factor for infectious diseases, but the mechanisms linking age to infectious disease risk are incompletely understood. Age-related mosaic chromosomal alterations (mCAs) detected from genotyping of blood-derived DNA, are structural somatic variants indicative of clonal hematopoiesis, and are associated with aberrant…[Read more]

Multimers consisting of 2 TeNT binding VHHs showed more than a 10-fold increase in affinity (KD of 4-23 pM) when compared to multimers containing only one TeNT binding VHH. The T6 and T16 VHHs showed synergistic in vivo TeNT neutralization and, when incorporated into a single VHH trimer (T6T16A12), they showed a very high TeNT neutralizing…[Read more]

However, due to a considerable burden for patients and the health budget, GH profiles are only used in few centres. Regarding genetic causes, there is good evidence of the existence of Kowarski syndrome (due to GH1 variants) but less on the role of GHSR variants. Several genetic causes of (partial) GHI are known (GHR, STAT5B, STAT3, IGF1, IGFALS…[Read more]

However, as we highlight, the Iceman’s equipment includes several technologies with a pre-Neolithic cultural origin. Earlier variants of these technologies were used by cultural groups belonging to the Mesolithic and even the Upper and Middle Paleolithic. Our main goal will be to present an explanatory framework for this macroevolutionary-scale…[Read more]

79, 95% confidence interval (CI) 0.66-0.95; P = 0.01]. Besides, Kaplan-Meier plots showed significant cause-specific survival advantage of NRT in intestinal type (P < 0.001), but not in diffuse type (P = 0.11) for T

N

patients. In the multivariate competing risk model, NRT still showed survival advantage only in T

N

patients (s…[Read more]

lly significant differences in performance mean values of 3D-GNC and fluoroscopy.

Technical success for the use of 3D-GNC to orient and position the endovascular device at each renal-visceral branch ostium was 100%. 3D-GNC resulted in 56% decrease in procedure time in comparison with standard fluoroscopic guidance (p<0.001). The 3D-GNC…[Read more]