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Finally, we validate how CRISpy-pop can accurately predict the activity of guide RNAs across strains using population genomic data.In the developing Xenopus tadpole visual system, the targeting and branching of optic axons in the brain is a dynamic process that is closely intertwined with the morphological differentiation and maturation of their…[Read more]

This study describes the influence of sex and disease phenotype on the occurrence of cardiac events in Fabry disease (FD).

Cardiac events from birth to last visit (median age 50 years) were recorded for 213 patients with FD. Patients were categorised as follows men with classical FD (n=57), men with non-classical FD (n=26), women with…[Read more]

It was found that burden in the caregiver could be linked with the presence of behavioural disorders, like aggression (r = 0.577; p = 0.008) and irritability (r = 0.600; p = 0.005) at the moderate stage of the disease. On the other hand, there is a positive correlation between the probability that people with dementia suffer abuse in the moderate…[Read more]

Drying-rewetting legacy affected the microbiome and CO2 emissions upon the following freezing-thawing cycle. Conversely, freezing-thawing legacy did not affect the microbial response to the drying-rewetting cycle. Our results suggest that drying-rewetting cycles have stronger effects on soil microbial communities and CO2 production than…[Read more]

The MQF is a flexible and efficient data structure that extends our ability to work with high throughput sequencing data.

Synthetic polymers present disadvantages such as high cost, limited availability, safety concerns, environmental hazards and accumulation in body. Lignin, an aromatic biopolymer, is highly abundant and offers various…[Read more]