Haastrup

72 (95% CI 3.48, 6.40;

 < 0.00001) compared with those without irAEs. Subgroup analyses suggested that the prognostic role of irAEs was associated with cancer types and region, but not irAEs types. The landmark analysis of OS revealed that there is a non-proportional (early) effect of irAEs on OS in ICI-treated cancer patients (la…[Read more]

Baseline TIGIT expression on peripheral T cells also correlated positively with Ki67 in tumor. Patients with higher baseline T-cell expression of TIM-3 had shorter PFS. Despite limited activity of pembrolizumab, this study highlights the immune phenotype in this rare tumor type before and after treatment. High baseline peripheral T-cell count and…[Read more]

is animal model. The results provide a scientific basis that curcumin could significantly alleviate the development of MN by inducing autophagy and alleviating renal oxidative stress through the PI3K/AKT/mTOR and Nrf2/HO-1 pathways.The higher alcohols produced by Saccharomyces cerevisiae exert remarkable influence on the taste and flavour of…[Read more]

4 and 68.7%, respectively. On the other hand, our proposed unsupervised learning model based on the integration of descriptor-relevance analysis and a Gaussian mixture model achieved an accuracy and recall score of 72.9 and 82.1%, respectively, which are significantly better than those of the supervised models. While capturing and interpreting the…[Read more]

The rainfall and distribution of rainwater drains explain the monthly and spatial variations of contribution of NO3–N sources well, respectively. In addition, less NO3–N in the urban channels derives from nitrification, which is consistent with the results of high properties of NH4+-N/TN in this region. Our results highlight the key roles of…[Read more]