Duke

Mass production technique of nanoscale TiO₂ particle-embedded expanded polystyrene (EPS) balls with temperature-controlled melting method was developed, and the photocatalytic activity of TiO₂-embedded EPS (TiEPS) balls to suppress the excessive growth of Microcystis aeruginosa (M. aeruginosa) cultured from both indoor and outdoor experiments was…[Read more]

PURPOSE  Finding effective methods of discriminating surgeon technical skill has proved a complex problem to solve computationally. Previous research has shown that obtaining non-expert crowd evaluations of surgical performances is as accurate as the gold standard, expert surgeon review. The aim of this research is (1) to learn whether…[Read more]

Nitroxides and nitroxide-containing nanoparticles (RNP) are excellent antioxidants. However, they have relatively high reduction potentials, which make them behave like oxidants or show little activity in some antioxidant assays. We found that stable nitroxyl radicals (TEMPO and 4-amino-TEMPO) has low reactivity in the test of scavenging of…[Read more]

Poly (ADP-ribose) polymerase (PARP) inhibitors have transformed the therapeutic management of solid tumors, particularly ovarian cancer. Initially studied in BRCA deficient tumors, the Food and Drug Administration (FDA) indications have expanded to include other homologous recombination deficient tumors as well as biomarker-wildtype tumors. They…[Read more]

Objective Nuclear grading is an independent prognosis factor of clear-cell renal cell carcinoma (ccRCC). A non-invasive preoperative predictive WHO/International Society of Urologic Pathology (WHO/ISUP) grading of ccRCC model is needed for clinical use. The anatomical complexity scoring system can span a variety of image modalities. The Centrality…[Read more]

Background Altered function of serotonin receptor 1A (5-HT1AR) has been consistently implicated in anxiety, major depressive disorder and resistance to antidepressants. Mechanisms by which the function of 5-HT1AR (expressed as an autoreceptor in serotonergic raphe neurons and as a heteroreceptor in serotonin [5-HT] projection areas) is altered…[Read more]

The rising global incidence of AD demands innovation that will help alleviate the burden to healthcare systems when coupled with the potentially near-term approval of disease-modifying therapies. Additionally, we argue that adequate infrastructure, equipment, and resources urgently should be integrated in the primary care setting to optimize the…[Read more]

Meanwhile, MAN enhanced autophagy flux by the increase of autophagosome formation, the fusion of autophagsomes and lysosomes and lysosomal function. Moreover, mTOR signaling pathway, a classical pathway regualting autophagy, was inhibited by MAN in a time- and dose-dependent mannner, resulting in autophagy induction. Interestingly, autophagy…[Read more]

Hofstadter’s butterfly spectrum, which characterizes the energy bands of electrons in a 2D lattice under a perpendicular magnetic field, has been emulated and experimentally characterized in periodic bandgap structures at microwave and acoustic frequencies. However, measurement of the complete spectrum at optical frequencies has yet to be…[Read more]