Suhr

Background Regorafenib is an inhibitor of multiple kinases with aberrant expression and activity in neuroblastoma tumours that have potential roles in neuroblastoma pathogenesis. Methods We evaluated neuroblastoma cells treated with regorafenib for cell viability and confluence, and analysed treated cells for apoptosis and cell cycle progression.…[Read more]

The mean percentage of anterior/posterior/all teeth with severe wear were 42.3 ± 28.1, 14.5 ± 19.9 and 30.0 ± 21.7. Anterior teeth, particularly the incisal surface of central incisors were most affected. The mean flow-rate of SWS and SPS were 0.1 ± 0.1 ml/min and 0.03 ± 0.07 ml/min respectively. Thirty (44.1 percent) and 48 (70.6 percent) partic…[Read more]

in English, Spanish El adenovirus del pollo serotipo 4 influye en el metabolismo de la arginina para favorecer su replicación. El síndrome de hidropericardio (HPS) es causado por el adenovirus del pollo serotipo 4 (FAdV-4). Este síndrome ha causado brotes en las poblaciones de pollo de engorde en China desde 2015. Sin embargo, se conoce poco so…[Read more]

The T Trials provided definitive evidence for short-term clinically meaningful, albeit modest benefits and risks of testosterone treatment in older men with unequivocal age-related hypogonadism. Larger and longer-term placebo-controlled clinical trials are needed to assess the long-term benefits and risks of testosterone treatment on clinical…[Read more]

AIMS AND OBJECTIVES To examine the understanding of caring in the practice of community nursing from the perspectives of patients and nurses. BACKGROUND An increasing population of patients with chronic disease has produced a need for humanistic caring in communities. As a result, caring has become a core value of community nursing professionals.…[Read more]

The findings contribute to the emerging understanding of the role of immunomodulation and inflammation in GDM and of galectin-2 itself. This might also have implications for the long-term cardiovascular health of the offspring.(1) Background Epithelial-mesenchymal transition (EMT) is an essential step for cancer metastasis; targeting EMT is an…[Read more]

The seven papers in this issue address a variety of challenges that parents in several different cultural places encounter as they do their best to ensure their children’s safe, happy, and successful development from infancy through middle childhood infant sleep, developmental agendas, temperament, preschools, academic success, and learning to be…[Read more]

Herein, a nanowelding technique is adopted to fabricate three-dimensional layer-by-layer Pd-containing nanocomposite structures with special properties. Nanowires fabricated from noble metals (Pd, Pt, Au, and Ag) were used to prepare Pd-Pd nanostructures and Pd-Au, Pd-Pt, Pd-Ag, and Pd-Pt-Au nanocomposite structures by controlling the welding…[Read more]

Cangrelor could be a potential therapeutic medicine for pulmonary fibrosis. The Na+/Ca2+ exchanger plays a relevant role in several neurological disorders, thus the pharmacological modulation of its isoforms might represent a promising strategy to ameliorate the course of some neurological pathologies including stroke, neonatal hypoxia, multiple…[Read more]

These studies suggest that many RDCs present in NSPCs are developmentally influenced to occur in this cell type and indicate that induced development of NPCs from ESCs provides an approach to rapidly elucidate mechanistic aspects of NPC RDC formation.Lipases are enzymes necessary for the proper distribution and utilization of lipids in the human…[Read more]

BACKGROUND 2′, 5′-oligoadenylate synthetase 2 (OAS2) has been known as an antiviral interferon-stimulated gene (ISG). However, the role of OAS2 on Zika virus (ZIKV) replication is still unknown. In this study, we sought to explore the effect of OAS2 on ZIKV replication and its underlying mechanism. METHODS We performed RNA-Seq in A549 cells with…[Read more]

Proteins on cell membrane are modified by N- and O-glycans. N-Glycans have been extensively characterized using advanced separation and mass spectrometry techniques. However, O-glycans remain a challenge, because of the lack of universal enzymes to release them and the large background abundances of N-glycans. Here, we report a method for in-depth…[Read more]