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The prevalence of hypertension among African Americans (AAs) in the US is among the highest of any demographic and affects over two-thirds of AA women. Previous data from our laboratory suggest substantial differential gene expression (DGE) of mRNAs and microRNAs (miRNAs) exists within peripheral blood mononuclear cells (PBMCs) isolated from AA…[Read more]

BACKGROUND Ursodeoxycholic acid (UDCA) is a secondary hydrophilic bile acid, metabolised in the gut, by microbiota. UDCA is currently prescribed for primary biliary cirrhosis, and of recently has shown β-cell protective effects, which suggests potential antidiabetic effects. Thus, this study aimed to design targeted-delivery microcapsules for…[Read more]

Postoperative pulmonary complications (PPCs) significantly impact surgical outcome. We investigated the predictive ability of controlling nutritional status (CONUT) for PPC after lung resection in patients with non-small cell lung cancer (NSCLC). We retrospectively reviewed data of 922 patients with NSCLC who underwent complete resection from…[Read more]

We further present hierarchical channel-wise interaction based binary convolutional neural networks (HCI-BCNN) to shrink the search space via hierarchical reinforcement learning. Moreover, we propose denoising interacted bitcount in binary convolution by smoothing the channel-wise interactions, so that noise in channel-wise priors can be…[Read more]

Here we describe three human C3/CVF hybrid proteins which differ in only one, two, or five amino acid residues from earlier described hybrid proteins. In all three cases, the hybrid proteins containing CVF residues form more stable convertases, and exhibit stronger complement-depletion activity than hybrid proteins with human C3 residues. Three…[Read more]

The IκB-Kinase (IKK)-NF-κB signalling pathway plays a multifaceted role in inflammatory bowel disease (IBD) on the one hand, it protects from apoptosis; on the other, it activates transcription of numerous inflammatory cytokines and chemokines. Although several murine models of IBD rely on disruption of IKK-NF-κB signalling, these involve ei…[Read more]

focused on off-label indications is needed to clarify whether they are effective, safe and cost-effective. © European Association of Hospital Pharmacists 2020. No commercial re-use. See rights and permissions. Published by BMJ.OBJECTIVE The associated risk of vascular disease following diagnosis of type 2 diabetes in people previously identified…[Read more]