Holst

Additionally, to enable in vitro functional studies of early placentation, we generated and thoroughly characterized two highly pure first trimester telomerase (TERT) immortalized rhesus trophoblast cell lines (iRP-D26 and iRP-D28A) that retained crucial features of isolated primary trophoblasts.

Overall, our findings help elucidate the…[Read more]

Melatonin treatment reduced LDH release and neuronal apoptosis at various time points, markedly increased Akt phosphorylation in neuronal membrane, but significantly suppressed it in the cytoplasm of post-OGD neurons. Mechanistically, melatonin-induced Akt phosphorylation and neuronal survival was blocked by Wortmannin, a potent PIP3 inhibitor,…[Read more]

Anterior cervical discectomy and fusion surgery is a common procedure for degenerative cervical spine. This describes allospacer and implant-related outcomes, comparing medium plate-low screw angle and short plate-high screw angle techniques.

From January 2016 to June 2019, 79 patients who underwent ACDF were prospectively enrolled.…[Read more]

Psychosocial stressors, such as perceived discrimination and depressive symptoms, may shorten telomeres and exacerbate aging-related illnesses.

Participants from the Jackson Heart Study at visit 1 (2000-2004) with LTL data and Center for Epidemiological Studies-Depression (CES-D) scores (

= 580 men,

= 910 women) were utilized. The…[Read more]

Thus, the birthplace of the lives or careers of those 4 pioneers of plastic surgery-Gillies, Pickerill, McIndoe, Mowlem-was Dunedin. Perhaps were it not for the fate of the Great World Wars it may have never been, but it was. BACKGROUND It is a generally accepted relationship that an increase in operative time results in an increase in…[Read more]

.59); AOR 1.72; 95% CI (1.20, 2.47)] were significantly associated with poor outcomes on disability, pain and global perception of change, respectively. Besides these factors, being employed reduces the chances of poor outcomes on disability [AOR 0.31; 95% CI (0.11, 0.92)]. CONCLUSIONS A large proportion of LBP patients seeking primary health care…[Read more]