Abrams

Sandro Galea and co-authors discuss a forthcoming Collection on data science and social determinants of health.Although movement ecology has leveraged models of home range formation to explore the effects of spatial heterogeneity and social cues on movement behavior, disease ecology has yet to integrate these potential drivers and mechanisms of…[Read more]

Radiosensitizers are needed to improve treatment response to radiation, which will directly influence patient outcomes in gastrointestinal cancers. This article reviews the literature to identify strategies – including DNA-targeting agents, antimetabolic agents, antiangiogenics and novel immunotherapies – being used to enhance radiosensitivity in…[Read more]

Reentrant facets of gold crystals that should be present according to their Wulff shape are not observed because these concave sites typically grow out due to kinetic considerations. This study demonstrates the significant effect of the crystal facet termination and surface reconstruction of an oxide substrate on the shape of supported gold…[Read more]

05). The presence of BIX02189, a specific inhibitor of MER/ERK, caused a much greater cytotoxicity, i.e., higher cell death, more ROS production, and worsened apoptosis, than did the treatment with Mn alone. Following Mn exposure, the expression of a downstream effector Bcl- 2 was reduced by 48 % while those of Bax and Caspase-3 were increased by…[Read more]