Hsu

Cannabis is one of the most widely used substances across the globe and its use has a substantial heritable component. However, the heritability of cannabis use varies according to substance use phenotype, suggesting that a unique profile of gene variants may contribute to the different stages of use, such as age of use onset, lifetime use,…[Read more]

EREG promoter hypermethylation in HPV

cells was confirmed using methylation-specific PCR (MS-PCR).

We conclude that EREG is the target of epigenetic regulation in HPV

HNCs and its suppressed expression through promoter hypermethylation is associated with the development of HPV-associated HNCs.

We conclude that EREG is the target…[Read more]

are is a key goal.Recent discoveries of mcr and mcr-like genes in genomes from diverse archaeal lineages suggest that methane metabolism is an ancient pathway with a complicated evolutionary history. One conventional view is that methanogenesis is an ancestral metabolism of the class Thermoplasmata. Through comparative genomic analysis of 12…[Read more]

In this study, we have investigated the enzyme shikimate 5-dehydrogenase from the causative agent of tuberculosis, Mycobacterium tuberculosis. We have employed a mixture of computational techniques, including molecular dynamics, hybrid quantum chemical/molecular mechanical potentials, relaxed surface scans, quantum chemical descriptors and…[Read more]

009) and a trend for current smoker status (p = 0.07). In CG, age ≥ 50years (p = 0.05) and disc degeneration (Pfirrmann p = 0.026, Kellgren and Lawrence p = 0.013) were predictive factors for reherniation.

In the current study, risk factors for early recurrent disc herniation after lumbar discectomy were age ≥ 50years and moder…[Read more]