Fuentes

The development of pulmonary fibrosis from sarcoidosis often causes major morbidity and mortality and should be a major focus of concern.Introduction Immune checkpoint inhibitor therapy and BRAF-targeted therapy have been developed for the treatment of metastatic melanoma. The optimal use of these agents, either in sequence or combination, for the…[Read more]

Migraine is characterized by moderate to severe recurrent headache lasting for 4-72h. Cortical hyperexcitability may play a crucial role in migraine onset. Therefore, antiepileptic drugs, such as levetiracetam, may be beneficial.

We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) and prospective…[Read more]

Furthermore, we constructed a 7-immune-related prognostic gene signature and found that the signature had high predictive value and was superior to other clinicopathological parameters. Finally, the correlation analysis of the signature with immune cell infiltration and immune checkpoint molecules suggested that the signature had the potential to…[Read more]

Total and marketable yields, fruit number per plant, and average fruit weight were significantly affected by E, G, and G × E interaction. Environmental component contributed 71-86% to the total variation for all these traits, while genotype explained 1.5-10.8%, and the contribution of G × E ranged between 4.3 to 6.7%. Estimation of the univariat…[Read more]

Antiretroviral therapy (ART) for HIV-1 infection is life-long. Stopping therapy typically leads to the reignition of infection and progressive disease. In a major breakthrough, recent studies have shown that early initiation of ART can lead to sustained post-treatment control of viremia, raising hopes of long-term HIV-1 remission. ART, however,…[Read more]

Several health benefits are currently attributed to natural pigments that give fruit and vegetables their inherently colorful properties. Color measurements might therefore serve as quick indicators of the potential health-promoting properties of such foods. Nevertheless, the relationship between color and pigment content depends on the type of…[Read more]

INTRODUCTION Severe open tibial fractures are limb-threatening injuries. Outcomes depend on a complex interplay of patient, injury and treatment factors. 2009 guidelines from the British Orthopaedic Association (BOA) and British Association of Plastic, Reconstructive and Aesthetic Surgeons (BAPRAS) recommend prophylactic intravenous antibiotic…[Read more]

Although recreational cannabis is now legal in Canada, little empirical evidence exists regarding young Canadians’ cannabis literacy, cannabis-related risk perceptions, and risk of different forms of cannabis or the effect that public health education may have on these perceptions. The present study sought to address these knowledge gaps to…[Read more]