McGuire

The least amount of soluble aggregates and subvisible particles were detected in the Bis-mAb formulations with the highest colloidal stability and refoldability from urea. We suggest that the optimization of these two features is crucial for obtaining physically stable formulations of Bis-mAb. OBJECTIVE To explore the current practice patterns for…[Read more]

The spinel LiMn2O4 (LMO) is a promising cathode material for rechargeable Li-ion batteries due to its excellent properties, including cost effectiveness, eco-friendliness, high energy density, and rate capability. The commercial application of LiMn2O4 is limited by its fast capacity fading during cycling, which lowers the electrochemical…[Read more]

This article is part of the theme issue ‘Measuring physiology in free-living animals (Part II)’.Drawing on insights from qualitative social science research, this paper aims to prompt reflection on social, ethical and regulatory challenges faced by scientists undertaking invasive animal research in the field and propose ways of addressing these…[Read more]

The World Health Organization (WHO) has proposed a plan for the elimination of viral hepatitis with a goal of reducing new hepatitis infections by 30% and 90% in 2020 and 2030, and associated mortality by 10% and 65% respectively. Actions and targets to reach these goals include improving hepatitis B virus (HBV) vaccination programs, the…[Read more]

There was a significant strong positive correlation between various parameters, that is, NLR and MLR (r 0.852, P=0), MPV and PDW (r 0.912, P=0), MPV and PLCR (r 0.956, P=0), PDW and PLCR (r 0.893, P=0). NLR (AUC 0.676, P=0) was the best single parameter and NLR+RDW-CV was best combination parameter as per area under curve (0.871) of ROC to…[Read more]

a procedure, and lengths of stay in the hospital and ICU. Obtaining comorbidity information when available from families can better allow the clinician to optimize treatment and educate loved ones about the potential effects of these comorbidities on the overall health of the patient. Understanding these correlations may allow for a better…[Read more]

Saxitoxin (STX) is a small molecule toxin (Mw. ca. 299 g/mol) with high acute toxicity, and it has urgent need of facile analytical methods. Herein, a competitive colorimetric aptasensor was developed for highly sensitive detection of STX. Selleck fMLP An anti-STX aptamer was hybridized with a complementary strand on the magnetic beads and was…[Read more]

ges in translation quality control in response to physiological cues can directly modulate bacterial persistence.We demonstrate here that the acquisition of DNase resistance by transforming DNA, often assumed to indicate transport to the cytoplasm, reflects uptake to the periplasm, requiring a reevaluation of conclusions about the roles of several…[Read more]