Espensen

Proteasomes are highly abundant and conserved protease complexes that eliminate unwanted proteins in the cells. As a single-chain ATP-independent nuclear proteasome activator, proteasome activator 200 (PA200) associates with 20S core particle to form proteasome complex that catalyzes polyubiquitin-independent degradation of acetylated histones,…[Read more]

Cognitively-defined subgroups are well-documented within neurodegeneration.

We examined such profiles in diverse non-demented older adults and considered how resulting subgroups relate to modifiable factors associated with neurodegeneration.

121 non-demented (MMSE = 28.62) diverse (46%non-Latino Black, 40%non-Latino White, 15%…[Read more]

The model also effectively reproduced the dose, dose rate and oxygen tension dependence of responses to FLASH radiotherapy in a range of systems, with model parameters compatible with published data. CONCLUSIONS Oxygen depletion provides a credible quantitative model to understand the biological effects of FLASH radiotherapy and is compatible with…[Read more]

Mechanically, our results indicate that an inhibitory effect of MTHFD2 knockdown may be mediated by the downregulation of cyclin B1/Cdc2 complex and the inhibitory effect on its activity. Additionally, MTHFD2 could regulate cell growth and aggressiveness via activation of STAT3 and the STAT3-induced epithelial-mesenchymal transition (EMT)…[Read more]

This work provides an effective strategy for augmenting CO-mediated antitumor efficacy by remodeling the tumor microenvironment.

Nurses play an important role in pharmaceutical care. They are involved in detecting clinical change; communicating/discussing pharmacotherapy with patients, their advocates, and other healthcare professionals;…[Read more]

Exposure to Cd caused the disruption of expression rhythm in clock genes, like clock1b, clock2, and cry1b, while only the rhythm of clock2 was disrupted in the co-exposure group. The results suggest that the behavioral rhythm disruption caused by Cd exposure is associated with the disturbance of certain circadian genes, whereas Pb exposure only…[Read more]