Gordon

Integrated drug efficacy surveillance (iDES) was formally introduced nationally across Thailand in fiscal year 2018 (FY2018), building on a history of drug efficacy monitoring and interventions. According to the National Malaria Elimination Strategy for Thailand 2017-2026, diagnosis is microscopically confirmed, treatment is prescribed, and…[Read more]

High-priority investigations were significantly more likely than medium- and low-priority investigations to have two or more cases among employees (p less then 0.001), two or more cases not previously linked to the workplace (p less then 0.001), or two or more exposed workplace contacts not previously identified during case interviews (p = 0.002).…[Read more]

BACKGROUND Coronavirus Disease 2019 (COVID-19) has been associated with a hypercoagulability state. Clinical presentation can range from asymptomatic to severe illness and mortality. Thrombotic complications in COVID-19 have been associated with mortality. The incidence of systemic hypercoagulation in COVID-19 is associated with the process of…[Read more]

06; CHQ, P < 0.05). In contrast, in C2C12 cells, 1mM leucine increased mTORC1 and S6K1 phosphorylation (P < 0.05), which was inhibited by 2mg/ml chloroquine. Chloroquine (2mg/ml) was sufficient to disrupt mTORC1 signaling, and MyPS.

Chloroquine did not inhibit amino acid-induced activation of mTORC1 signaling and skeletal MPS in humans…[Read more]

Pulmonary embolism (PE) is a life-threatening condition characterized by occlusive disease of the pulmonary vasculature. Point-of-care ultrasound (POCUS) of right ventricular strain patterns have high specificity and low sensitivity for diagnosis. Here, we describe a patient with a saddle PE and low pre-test probability who was diagnosed primarily…[Read more]

The mean distribution of preoperative obstruction level could be divided into the following 38% velar, 46% multilevel, and 16% infravelar obstructions. Patients with a good treatment response (defined as AHI < 15/h and AHI reduction of 50%) had fewer preoperative velar obstructions compared to non-responder (17% vs. 54%, p-value = 0.006). In pati…[Read more]