Activity

The results showed that the properties of asparagus pomace did not always improve gradually with decreasing particle size. With a decrease in granularity, some parameters showed a bell-shaped curve whereas others initially increased and then stabilized, indicating that in actual production, the crushing particle size should be determined according to actual needs or target parameters.Objective The aim was to evaluate the association between oral health-related quality of life (OHRQol) and periodontal status in patients with leukemia. Methods A total of 55 patients with leukemia (42.09 ± 16.57 years, 27.3% females) answered the Oral Health Impact Profile, short version (OHIP-14) and underwent a periodontal examination. Associations between periodontal status and total mean OHIP-14 scores were analysed, and the prevalence of high scores was identified for each group. Results A total mean OHIP-14 score of 13.18 was observed for the entire sample. The corresponding total mean OHIP-14 scores for patients with moderate (n = 18), absent/mild (n = 24), and severe periodontitis (n = 13) were 17.11, 12.50, and 9.00 (P = 0.061), respectively. A higher prevalence of high scores was found for the ‘feeling ill-at-ease’ question (psychological discomfort domain) for absent/mild and moderate periodontitis patients, whereas those with severe periodontitis had higher prevalence on the ‘feeling embarrassed’ question (psychosocial disability domain). In the adjusted analysis, hospitalisation was associated with higher OHIP-14 scores (β = 8.49; 95% CI 1.89-15.08; P = 0.013). Higher OHIP-14 scores were not significantly associated with either patients presenting >15% sites with gingival bleeding or those with moderate/severe periodontitis. Conclusion Leukemia was associated with a negative influence on OHRQoL. However, this association was better explained by the patient’s systemic condition than by an impact of its periodontal condition. Nonetheless, patients with leukemia presented with gingivitis and/or periodontitis, pointing to the need for oral health care for these individuals.Background Species belonging to the genus Aspergillus have been used in traditional Japanese fermented foods. Aspergillus sojae is a species responsible for strong proteolytic activity. Freeze-drying treatments followed by physical disruption enables the pulverization of the mycelia of A. sojae RIB 1045 grown in whey protein-base solid media. Intracellular proteases were extracted using this protocol to compare extracellular protease activity in terms of the reaction’s pH dependence in the presence or absence of inhibitors. Result With different sensitivities to inhibitors, intracellular and extracellular proteases showed the strongest activity under acidic conditions, which were considered suitable for cheese application. The raw culture product (CP) and its freeze-dried product (FDP) were mixed with cheese curds, prepared according to Gouda-type cheese-making methods, and were allowed to ripen for 3 months. Chemical analysis of the products showed 13.3% water-soluble nitrogen (WSN) in the control, which had received noncultured media, whereas 20.0% and 21.1% WSN was found in the CP and FDP experimental cheeses, respectively. Although these adjuncts significantly increased WSN, an insignificant difference was found between CP and FDP. Free fatty acids in all experimental cheeses were similar, showing that CP and FDP caused no rancid defects. Conclusion The introduction of freeze-drying treatments accompanied by cell disruption resulted in a negligible effect in terms of WSN. However, the application of A. sojae can be beneficial when it comes to increasing the level of WSN compared with A. read more oryzae, as shown in our previous study. © 2020 Society of Chemical Industry.Advances in tissue clearing and microscopy make it possible to study human diseases in 3-dimensions (3-D). High-grade tumor budding (TB) is known to be associated with poor prognosis in various cancers; however, little is known about the 3-D architecture of TB. Using tissue clearing, we analyzed the 3-D structure of TB and E-cadherin expression in 31 extrahepatic cholangiocarcinomas. A total of 31 thick slabs (up to 5 mm) were harvested from surgically resected tumor tissue, including 27 hilar and 4 distal cholangiocarcinomas. Twenty-eight cases were adenocarcinoma, and three were undifferentiated carcinoma. After clearing, the tissues were immunolabeled with antibodies to cytokeratin 19 and to E-cadherin, and then visualized using light-sheet and confocal laser scanning microscopy. TB was evaluated in hematoxylin and eosin stained sections (2-D) using standard pathological criteria. Of the 31 cancers, 13 showed low-grade TB and 18 showed high-grade TB. First, 3-D analysis revealed that the neoplastic cells iy copyright. All rights reserved.We replicated Shillingsburg et al. (2018) by teaching children with autism to mand for social information while analyzing the variables influencing the emission of mands. We presented questions about a social partner that were known and observable (e.g., “What is Robin doing?”), known but unobservable (i.e., questions for which an intraverbal response had previously been taught, such as, “Where does Robin work?”), or unknown (e.g., “What is Robin’s favorite food?”). Correct answers were reinforced across all conditions. During treatment, we prompted children to mand for information from the social partner following only unknown questions. All children acquired mands for social information and answered previously unknown questions correctly after manding for social information and 3 of 4 participants emitted mands to novel social partners, including a peer with autism.Background Emerging infectious diseases pose a great hazard to public health and the global economy. A novel coronavirus, SARS-CoV-2, causing coronavirus disease 2019 (COVID-19), emerged from Wuhan, China, in December 2019. Since then, it has spread globally causing a global health emergency of inconceivable magnitude, with significant morbidity and mortality. There is the need for clinicians and health care providers to understand and gain knowledge of the different aspects of the disease as it evolves. Objective We reviewed existing literature on COVID-19 in order to present a synopsis of current understanding of the disease. Methods Using PubMed, Embase and Medline, articles published between January and April 2020 on Coronavirus disease 2019 (COVID-19), and resources from World Health Organisation were analyzed in order to have an understanding of the clinical characteristics, transmission dynamics, virology, diagnostic possibilities, prevention, management approach, controversies and impact of COVID-19 on the healthcare workforce.